Small RNA 2'-O-methyltransferase (HENMT1)
Homo sapiens — UniProt Q5T8I9
Data last refreshed: (UniProt release unknown)
Key facts
Small RNA 2'-O-methyltransferase (HENMT1) is a protein from Homo sapiens identified by UniProt accession Q5T8I9, 393 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.
- UniProt accession: Q5T8I9; gene symbol HENMT1.
- Organism: Homo sapiens.
- Length: 393 amino acids.
- Top disease associations (Open Targets): azoospermia, neurodegenerative disease and cutaneous melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small RNA 2'-O-methyltransferase |
|---|---|
| UniProt accession | Q5T8I9 |
| Gene | HENMT1 |
| Organism | Homo sapiens |
| Length | 393 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (128)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.44
- neurodegenerative disease · score 0.38
- cutaneous melanoma · score 0.15
- male infertility · score 0.12
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.09
- mean platelet volume · score 0.08
- spermatogenic failure 65 · score 0.08
- spermatogenic failure 10 · score 0.08
- spermatogenic failure 11 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5T8I9-F1 | alphafold | PREDICTED | 85.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5T8I9.
Amino-acid sequence (393 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HENMT1?
The strongest Open Targets associations for HENMT1 are azoospermia, neurodegenerative disease, cutaneous melanoma, male infertility and male infertility with teratozoospermia due to single gene mutation.
How long is the HENMT1 protein?
The Homo sapiens HENMT1 protein (UniProt Q5T8I9) is 393 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5T8I9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5T8I9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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