Tetratricopeptide repeat protein 22 (TTC22)
Homo sapiens — UniProt Q5TAA0
Data last refreshed: (UniProt release unknown)
Key facts
Tetratricopeptide repeat protein 22 (TTC22) is a protein from Homo sapiens identified by UniProt accession Q5TAA0, 569 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q5TAA0; gene symbol TTC22.
- Organism: Homo sapiens.
- Length: 569 amino acids.
- Top disease associations (Open Targets): colorectal cancer, colorectal adenoma and pancreatic neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tetratricopeptide repeat protein 22 |
|---|---|
| UniProt accession | Q5TAA0 |
| Gene | TTC22 |
| Organism | Homo sapiens |
| Length | 569 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- colorectal cancer · score 0.33
- colorectal adenoma · score 0.26
- pancreatic neoplasm · score 0.07
- osteoarthritis, hand · score 0.05
- visceral adipose tissue measurement · score 0.05
- white matter microstructure measurement · score 0.05
- phospholipid measurement · score 0.05
- neoplasm · score 0.04
- cancer · score 0.03
- metabolite measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5TAA0-F1 | alphafold | PREDICTED | 89.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5TAA0.
Amino-acid sequence (569 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TTC22?
The strongest Open Targets associations for TTC22 are colorectal cancer, colorectal adenoma, pancreatic neoplasm, osteoarthritis, hand and visceral adipose tissue measurement.
How long is the TTC22 protein?
The Homo sapiens TTC22 protein (UniProt Q5TAA0) is 569 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5TAA0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5TAA0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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