Protein ripply2 (RIPPLY2)
Homo sapiens — UniProt Q5TAB7
Data last refreshed: (UniProt release unknown)
Key facts
Protein ripply2 (RIPPLY2) is a protein from Homo sapiens identified by UniProt accession Q5TAB7, 128 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q5TAB7; gene symbol RIPPLY2.
- Organism: Homo sapiens.
- Length: 128 amino acids.
- Top disease associations (Open Targets): autosomal recessive spondylocostal dysostosis, Klippel-Feil syndrome 2, autosomal recessive and brachyolmia, Maroteaux type.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein ripply2 |
|---|---|
| UniProt accession | Q5TAB7 |
| Gene | RIPPLY2 |
| Organism | Homo sapiens |
| Length | 128 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- autosomal recessive spondylocostal dysostosis · score 0.54
- Klippel-Feil syndrome 2, autosomal recessive · score 0.27
- brachyolmia, Maroteaux type · score 0.06
- urate measurement · score 0.06
- bone density · score 0.06
- Scheuermann disease · score 0.05
- autosomal dominant spondylocostal dysostosis · score 0.05
- autosomal dominant brachyolmia · score 0.05
- spondylocamptodactyly syndrome · score 0.05
- cervical spondylosis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5TAB7-F1 | alphafold | PREDICTED | 60.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5TAB7.
Amino-acid sequence (128 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RIPPLY2?
The strongest Open Targets associations for RIPPLY2 are autosomal recessive spondylocostal dysostosis, Klippel-Feil syndrome 2, autosomal recessive, brachyolmia, Maroteaux type, urate measurement and bone density.
How long is the RIPPLY2 protein?
The Homo sapiens RIPPLY2 protein (UniProt Q5TAB7) is 128 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5TAB7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5TAB7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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