DDB1- and CUL4-associated factor 8 (DCAF8)
Homo sapiens — UniProt Q5TAQ9
Data last refreshed: (UniProt release unknown)
Key facts
DDB1- and CUL4-associated factor 8 (DCAF8) is a protein from Homo sapiens identified by UniProt accession Q5TAQ9, 597 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.
- UniProt accession: Q5TAQ9; gene symbol DCAF8.
- Organism: Homo sapiens.
- Length: 597 amino acids.
- Top disease associations (Open Targets): giant axonal neuropathy 2, neurodegenerative disease and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DDB1- and CUL4-associated factor 8 |
|---|---|
| UniProt accession | Q5TAQ9 |
| Gene | DCAF8 |
| Organism | Homo sapiens |
| Length | 597 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (87)
Diseases linked to this target (Open Targets).
- giant axonal neuropathy 2 · score 0.60
- neurodegenerative disease · score 0.50
- lysosomal storage disease · score 0.37
- FEV/FVC ratio · score 0.14
- neurofibromatosis type 1 · score 0.11
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure 65 · score 0.06
- spermatogenic failure 72 · score 0.06
- spermatogenic failure 51 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5TAQ9-F1 | alphafold | PREDICTED | 74.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5TAQ9.
Amino-acid sequence (597 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCAF8?
The strongest Open Targets associations for DCAF8 are giant axonal neuropathy 2, neurodegenerative disease, lysosomal storage disease, FEV/FVC ratio and neurofibromatosis type 1.
How long is the DCAF8 protein?
The Homo sapiens DCAF8 protein (UniProt Q5TAQ9) is 597 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5TAQ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5TAQ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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