DEP domain-containing protein 1A (DEPDC1)
Homo sapiens — UniProt Q5TB30
Data last refreshed: (UniProt release unknown)
Key facts
DEP domain-containing protein 1A (DEPDC1) is a protein from Homo sapiens identified by UniProt accession Q5TB30, 811 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.
- UniProt accession: Q5TB30; gene symbol DEPDC1.
- Organism: Homo sapiens.
- Length: 811 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, high density lipoprotein cholesterol measurement and smoking status measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DEP domain-containing protein 1A |
|---|---|
| UniProt accession | Q5TB30 |
| Gene | DEPDC1 |
| Organism | Homo sapiens |
| Length | 811 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (114)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.24
- high density lipoprotein cholesterol measurement · score 0.21
- smoking status measurement · score 0.21
- cognitive function measurement · score 0.20
- intelligence · score 0.20
- hepatocellular carcinoma · score 0.12
- Hirschsprung disease · score 0.11
- Aganglionic megacolon · score 0.11
- oral squamous cell carcinoma · score 0.10
- non-small cell lung carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5TB30-F1 | alphafold | PREDICTED | 60.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5TB30.
Amino-acid sequence (811 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEPDC1?
The strongest Open Targets associations for DEPDC1 are self reported educational attainment, high density lipoprotein cholesterol measurement, smoking status measurement, cognitive function measurement and intelligence.
How long is the DEPDC1 protein?
The Homo sapiens DEPDC1 protein (UniProt Q5TB30) is 811 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5TB30 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5TB30 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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