Ribonuclease H2 subunit B (RNASEH2B)
Homo sapiens — UniProt Q5TBB1
Data last refreshed: (UniProt release unknown)
Key facts
Ribonuclease H2 subunit B (RNASEH2B) is a protein from Homo sapiens identified by UniProt accession Q5TBB1, 312 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.
- UniProt accession: Q5TBB1; gene symbol RNASEH2B.
- Organism: Homo sapiens.
- Length: 312 amino acids.
- Top disease associations (Open Targets): Aicardi-Goutières syndrome, Aicardi-Goutieres syndrome and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ribonuclease H2 subunit B |
|---|---|
| UniProt accession | Q5TBB1 |
| Gene | RNASEH2B |
| Organism | Homo sapiens |
| Length | 312 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (98)
Diseases linked to this target (Open Targets).
- Aicardi-Goutières syndrome · score 0.84
- Aicardi-Goutieres syndrome · score 0.50
- mean corpuscular volume · score 0.46
- mean corpuscular hemoglobin concentration · score 0.38
- autism spectrum disorder · score 0.37
- mean corpuscular hemoglobin · score 0.36
- Abnormality of the nervous system · score 0.34
- Aicardi-Goutieres syndrome 1 · score 0.34
- genetic disorder · score 0.34
- cerebral palsy · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5TBB1-F1 | alphafold | PREDICTED | 76.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5TBB1.
Amino-acid sequence (312 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNASEH2B?
The strongest Open Targets associations for RNASEH2B are Aicardi-Goutières syndrome, Aicardi-Goutieres syndrome, mean corpuscular volume, mean corpuscular hemoglobin concentration and autism spectrum disorder.
How long is the RNASEH2B protein?
The Homo sapiens RNASEH2B protein (UniProt Q5TBB1) is 312 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5TBB1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5TBB1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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