NEDD4-binding protein 2-like 1 (N4BP2L1)
Homo sapiens — UniProt Q5TBK1
Data last refreshed: (UniProt release unknown)
Key facts
NEDD4-binding protein 2-like 1 (N4BP2L1) is a protein from Homo sapiens identified by UniProt accession Q5TBK1, 243 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.
- UniProt accession: Q5TBK1; gene symbol N4BP2L1.
- Organism: Homo sapiens.
- Length: 243 amino acids.
- Top disease associations (Open Targets): low density lipoprotein cholesterol measurement, apolipoprotein B measurement and response to statin.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NEDD4-binding protein 2-like 1 |
|---|---|
| UniProt accession | Q5TBK1 |
| Gene | N4BP2L1 |
| Organism | Homo sapiens |
| Length | 243 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (65)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.46
- apolipoprotein B measurement · score 0.34
- response to statin · score 0.32
- physical activity · score 0.25
- total cholesterol measurement · score 0.23
- Hypercholesterolemia · score 0.22
- basal cell carcinoma · score 0.15
- keratinocyte carcinoma · score 0.15
- squamous cell carcinoma · score 0.14
- nasal cavity cancer · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5TBK1-F1 | alphafold | PREDICTED | 78.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5TBK1.
Amino-acid sequence (243 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with N4BP2L1?
The strongest Open Targets associations for N4BP2L1 are low density lipoprotein cholesterol measurement, apolipoprotein B measurement, response to statin, physical activity and total cholesterol measurement.
How long is the N4BP2L1 protein?
The Homo sapiens N4BP2L1 protein (UniProt Q5TBK1) is 243 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5TBK1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5TBK1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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