Cytochrome P450 4A22 (CYP4A22)
Homo sapiens — UniProt Q5TCH4
Data last refreshed: (UniProt release unknown)
Key facts
Cytochrome P450 4A22 (CYP4A22) is a protein from Homo sapiens identified by UniProt accession Q5TCH4, 519 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.
- UniProt accession: Q5TCH4; gene symbol CYP4A22.
- Organism: Homo sapiens.
- Length: 519 amino acids.
- Top disease associations (Open Targets): cutaneous melanoma, endometrial cancer and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytochrome P450 4A22 |
|---|---|
| UniProt accession | Q5TCH4 |
| Gene | CYP4A22 |
| Organism | Homo sapiens |
| Length | 519 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (111)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.26
- endometrial cancer · score 0.18
- head and neck squamous cell carcinoma · score 0.13
- urinary bladder cancer · score 0.11
- lung adenocarcinoma · score 0.08
- coronary artery disease · score 0.07
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.07
- focal segmental glomerulosclerosis · score 0.07
- IGA glomerulonephritis · score 0.07
- glomerulopathy with fibronectin deposits 2 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5TCH4-F1 | alphafold | PREDICTED | 89.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5TCH4.
Amino-acid sequence (519 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CYP4A22?
The strongest Open Targets associations for CYP4A22 are cutaneous melanoma, endometrial cancer, head and neck squamous cell carcinoma, urinary bladder cancer and lung adenocarcinoma.
How long is the CYP4A22 protein?
The Homo sapiens CYP4A22 protein (UniProt Q5TCH4) is 519 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5TCH4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5TCH4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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