Arginine-hydroxylase NDUFAF5, mitochondrial (NDUFAF5)
Homo sapiens — UniProt Q5TEU4
Data last refreshed: (UniProt release unknown)
Key facts
Arginine-hydroxylase NDUFAF5, mitochondrial (NDUFAF5) is a protein from Homo sapiens identified by UniProt accession Q5TEU4, 345 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q5TEU4; gene symbol NDUFAF5.
- Organism: Homo sapiens.
- Length: 345 amino acids.
- Top disease associations (Open Targets): mitochondrial complex I deficiency, Leigh syndrome and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Arginine-hydroxylase NDUFAF5, mitochondrial |
|---|---|
| UniProt accession | Q5TEU4 |
| Gene | NDUFAF5 |
| Organism | Homo sapiens |
| Length | 345 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- mitochondrial complex I deficiency · score 0.73
- Leigh syndrome · score 0.58
- genetic disorder · score 0.39
- mitochondrial disease · score 0.37
- Leber plus disease · score 0.32
- PHF-tau measurement · score 0.26
- neurodegenerative disease · score 0.16
- drug use measurement · score 0.10
- cancer · score 0.06
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5TEU4-F1 | alphafold | PREDICTED | 85.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5TEU4.
Amino-acid sequence (345 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NDUFAF5?
The strongest Open Targets associations for NDUFAF5 are mitochondrial complex I deficiency, Leigh syndrome, genetic disorder, mitochondrial disease and Leber plus disease.
How long is the NDUFAF5 protein?
The Homo sapiens NDUFAF5 protein (UniProt Q5TEU4) is 345 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5TEU4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5TEU4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.