Hepatoma-derived growth factor-like protein 1 (HDGFL1)
Homo sapiens — UniProt Q5TGJ6
Data last refreshed: (UniProt release unknown)
Key facts
Hepatoma-derived growth factor-like protein 1 (HDGFL1) is a protein from Homo sapiens identified by UniProt accession Q5TGJ6, 251 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q5TGJ6; gene symbol HDGFL1.
- Organism: Homo sapiens.
- Length: 251 amino acids.
- Top disease associations (Open Targets): coronary artery disease, electrocardiography and PR interval.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hepatoma-derived growth factor-like protein 1 |
|---|---|
| UniProt accession | Q5TGJ6 |
| Gene | HDGFL1 |
| Organism | Homo sapiens |
| Length | 251 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.45
- electrocardiography · score 0.39
- PR interval · score 0.38
- mean platelet volume · score 0.37
- platelet count · score 0.36
- BMI-adjusted waist circumference · score 0.30
- vitamin D measurement · score 0.29
- heart failure · score 0.29
- myocardial infarction · score 0.29
- Agents acting on the renin-angiotensin system use measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5TGJ6-F1 | alphafold | PREDICTED | 64.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5TGJ6.
Amino-acid sequence (251 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HDGFL1?
The strongest Open Targets associations for HDGFL1 are coronary artery disease, electrocardiography, PR interval, mean platelet volume and platelet count.
How long is the HDGFL1 protein?
The Homo sapiens HDGFL1 protein (UniProt Q5TGJ6) is 251 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5TGJ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5TGJ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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