Transmembrane and coiled-coil domain-containing protein 4 (TMCO4)
Homo sapiens — UniProt Q5TGY1
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane and coiled-coil domain-containing protein 4 (TMCO4) is a protein from Homo sapiens identified by UniProt accession Q5TGY1, 634 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: Q5TGY1; gene symbol TMCO4.
- Organism: Homo sapiens.
- Length: 634 amino acids.
- Top disease associations (Open Targets): inflammatory bowel disease, ulcerative colitis and chronotype measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane and coiled-coil domain-containing protein 4 |
|---|---|
| UniProt accession | Q5TGY1 |
| Gene | TMCO4 |
| Organism | Homo sapiens |
| Length | 634 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease · score 0.20
- ulcerative colitis · score 0.15
- chronotype measurement · score 0.14
- circadian rhythm · score 0.10
- bipolar I disorder · score 0.07
- Crohn's disease · score 0.06
- psoriasis · score 0.05
- ankylosing spondylitis · score 0.05
- sclerosing cholangitis · score 0.05
- vital capacity · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5TGY1-F1 | alphafold | PREDICTED | 71.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5TGY1.
Amino-acid sequence (634 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMCO4?
The strongest Open Targets associations for TMCO4 are inflammatory bowel disease, ulcerative colitis, chronotype measurement, circadian rhythm and bipolar I disorder.
How long is the TMCO4 protein?
The Homo sapiens TMCO4 protein (UniProt Q5TGY1) is 634 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5TGY1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5TGY1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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