von Willebrand factor A domain-containing protein 5B1 (VWA5B1)
Homo sapiens — UniProt Q5TIE3
Data last refreshed: (UniProt release unknown)
Key facts
von Willebrand factor A domain-containing protein 5B1 (VWA5B1) is a protein from Homo sapiens identified by UniProt accession Q5TIE3, 1220 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q5TIE3; gene symbol VWA5B1.
- Organism: Homo sapiens.
- Length: 1220 amino acids.
- Top disease associations (Open Targets): type 2 diabetes mellitus, vital capacity and hematocrit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | von Willebrand factor A domain-containing protein 5B1 |
|---|---|
| UniProt accession | Q5TIE3 |
| Gene | VWA5B1 |
| Organism | Homo sapiens |
| Length | 1220 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.31
- vital capacity · score 0.27
- hematocrit · score 0.08
- hemoglobin measurement · score 0.07
- red blood cell density measurement · score 0.03
- Abnormality of refraction · score 0.02
- ulcerative colitis · score 0.02
- Crohn's disease · score 0.01
- Tetralogy of Fallot · score 0.00
- juvenile idiopathic arthritis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5TIE3-F1 | alphafold | PREDICTED | 66.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5TIE3.
Amino-acid sequence (1220 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VWA5B1?
The strongest Open Targets associations for VWA5B1 are type 2 diabetes mellitus, vital capacity, hematocrit, hemoglobin measurement and red blood cell density measurement.
How long is the VWA5B1 protein?
The Homo sapiens VWA5B1 protein (UniProt Q5TIE3) is 1220 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5TIE3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5TIE3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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