Rootletin (CROCC)

Homo sapiens — UniProt Q5TZA2

Gene: CROCCHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Rootletin (CROCC) is a protein from Homo sapiens identified by UniProt accession Q5TZA2, 2017 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.

UniProt accession: Q5TZA2; gene symbol CROCC.
Organism: Homo sapiens.
Length: 2017 amino acids.
Top disease associations (Open Targets): erythrocyte count, red blood cell density measurement and Premature ovarian insufficiency.
3D structure: AlphaFold model available.

Target properties

Protein name	Rootletin
UniProt accession	Q5TZA2
Gene	CROCC
Organism	Homo sapiens
Length	2017 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (77)

Diseases linked to this target (Open Targets).

erythrocyte count · score 0.21
red blood cell density measurement · score 0.18
Premature ovarian insufficiency · score 0.14
FEV change measurement · score 0.13
BMI-adjusted waist-hip ratio · score 0.13
BMI-adjusted waist circumference · score 0.12
body height · score 0.11
body fat distribution · score 0.11
smoking behavior · score 0.11
lean body mass · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5TZA2-F1	alphafold	PREDICTED	69.01	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5TZA2.

Amino-acid sequence (2017 residues)

MSLGLAGAQE VELTLETVIQ TLESSVLCQE KGLGARDLAQ DAQITSLPAL IREIVTRNLS QPESPVLLPA TEMASLLSLQ EENQLLQQEL SRVEDLLAQS RAERDELAIK YNAVSERLEQ ALRLEPGELE TQEPRGLVRQ SVELRRQLQE EQASYRRKLQ AYQEGQQRQA QLVQRLQGKI LQYKKRCSEL EQQLLERSGE LEQQRLRDTE HSQDLESALI RLEEEQQRSA SLAQVNAMLR EQLDQAGSAN QALSEDIRKV TNDWTRCRKE LEHREAAWRR EEESFNAYFS NEHSRLLLLW RQVVGFRRLV SEVKMFTERD LLQLGGELAR TSRAVQEAGL GLSTGLRLAE SRAEAALEKQ ALLQAQLEEQ LRDKVLREKD LAQQQMQSDL DKADLSARVT ELGLAVKRLE KQNLEKDQVN KDLTEKLEAL ESLRLQEQAA LETEDGEGLQ QTLRDLAQAV LSDSESGVQL SGSERTADAS NGSLRGLSGQ RTPSPPRRSS PGRGRSPRRG PSPACSDSST LALIHSALHK RQLQVQDMRG RYEASQDLLG TLRKQLSDSE SERRALEEQL QRLRDKTDGA MQAHEDAQRE VQRLRSANEL LSREKSNLAH SLQVAQQQAE ELRQEREKLQ AAQEELRRQR DRLEEEQEDA VQDGARVRRE LERSHRQLEQ LEGKRSVLAK ELVEVREALS RATLQRDMLQ AEKAEVAEAL TKAEAGRVEL ELSMTKLRAE EASLQDSLSK LSALNESLAQ DKLDLNRLVA QLEEEKSALQ GRQRQAEQEA TVAREEQERL EELRLEQEVA RQGLEGSLRV AEQAQEALEQ QLPTLRHERS QLQEQLAQLS RQLSGREQEL EQARREAQRQ VEALERAARE KEALAKEHAG LAVQLVAAER EGRTLSEEAT RLRLEKEALE GSLFEVQRQL AQLEARREQL EAEGQALLLA KETLTGELAG LRQQIIATQE KASLDKELMA QKLVQAEREA QASLREQRAA HEEDLQRLQR EKEAAWRELE AERAQLQSQL QREQEELLAR LEAEKEELSE EIAALQQERD EGLLLAESEK QQALSLKESE KTALSEKLMG TRHSLATISL EMERQKRDAQ SRQEQDRSTV NALTSELRDL RAQREEAAAA HAQEVRRLQE QARDLGKQRD SCLREAEELR TQLRLLEDAR DGLRRELLEA QRKLRESQEG REVQRQEAGE LRRSLGEGAK EREALRRSNE ELRSAVKKAE SERISLKLAN EDKEQKLALL EEARTAVGKE AGELRTGLQE VERSRLEARR ELQELRRQMK MLDSENTRLG RELAELQGRL ALGERAEKES RRETLGLRQR LLKGEASLEV MRQELQVAQR KLQEQEGEFR TRERRLLGSL EEARGTEKQQ LDHARGLELK LEAARAEAAE LGLRLSAAEG RAQGLEAELA RVEVQRRAAE AQLGGLRSAL RRGLGLGRAP SPAPRPVPGS PARDAPAEGS GEGLNSPSTL ECSPGSQPPS PGPATSPASP DLDPEAVRGA LREFLQELRS AQRERDELRT QTSALNRQLA EMEAERDSAT SRARQLQKAV AESEEARRSV DGRLSGVQAE LALQEESVRR SERERRATLD QVATLERSLQ ATESELRASQ EKISKMKANE TKLEGDKRRL KEVLDASESR TVKLELQRRS LEGELQRSRL GLSDREAQAQ ALQDRVDSLQ RQVADSEVKA GTLQLTVERL NGALAKVEES EGALRDKVRG LTEALAQSSA SLNSTRDKNL HLQKALTACE HDRQVLQERL DAARQALSEA RKQSSSLGEQ VQTLRGEVAD LELQRVEAEG QLQQLREVLR QRQEGEAAAL NTVQKLQDER RLLQERLGSL QRALAQLEAE KREVERSALR LEKDRVALRR TLDKVEREKL RSHEDTVRLS AEKGRLDRTL TGAELELAEA QRQIQQLEAQ VVVLEQSHSP AQLEVDAQQQ QLELQQEVER LRSAQAQTER TLEARERAHR QRVRGLEEQV STLKGQLQQE LRRSSAPFSP PSGPPEK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with CROCC?

The strongest Open Targets associations for CROCC are erythrocyte count, red blood cell density measurement, Premature ovarian insufficiency, FEV change measurement and BMI-adjusted waist-hip ratio.

How long is the CROCC protein?

The Homo sapiens CROCC protein (UniProt Q5TZA2) is 2017 amino acids long.

Browse: Targets: C · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q5TZA2 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q5TZA2 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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