Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2)
Homo sapiens — UniProt Q5U5R9
Data last refreshed: (UniProt release unknown)
Key facts
Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2) is a protein from Homo sapiens identified by UniProt accession Q5U5R9, 776 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q5U5R9; gene symbol HECTD2.
- Organism: Homo sapiens.
- Length: 776 amino acids.
- Top disease associations (Open Targets): mitochondrial heteroplasmy measurement, clear cell renal carcinoma and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable E3 ubiquitin-protein ligase HECTD2 |
|---|---|
| UniProt accession | Q5U5R9 |
| Gene | HECTD2 |
| Organism | Homo sapiens |
| Length | 776 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- mitochondrial heteroplasmy measurement · score 0.23
- clear cell renal carcinoma · score 0.18
- body mass index · score 0.17
- body height · score 0.10
- hemoglobin measurement · score 0.10
- neoplasm · score 0.09
- renal cell carcinoma · score 0.08
- melanoma · score 0.08
- hepatocellular carcinoma · score 0.07
- hematocrit · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5U5R9-F1 | alphafold | PREDICTED | 80.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5U5R9.
Amino-acid sequence (776 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HECTD2?
The strongest Open Targets associations for HECTD2 are mitochondrial heteroplasmy measurement, clear cell renal carcinoma, body mass index, body height and hemoglobin measurement.
How long is the HECTD2 protein?
The Homo sapiens HECTD2 protein (UniProt Q5U5R9) is 776 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5U5R9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5U5R9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.