Protein FAM222A (FAM222A)
Homo sapiens — UniProt Q5U5X8
Data last refreshed: (UniProt release unknown)
Key facts
Protein FAM222A (FAM222A) is a protein from Homo sapiens identified by UniProt accession Q5U5X8, 452 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q5U5X8; gene symbol FAM222A.
- Organism: Homo sapiens.
- Length: 452 amino acids.
- Top disease associations (Open Targets): angina pectoris, self reported educational attainment and Abnormal brain morphology.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein FAM222A |
|---|---|
| UniProt accession | Q5U5X8 |
| Gene | FAM222A |
| Organism | Homo sapiens |
| Length | 452 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- angina pectoris · score 0.36
- self reported educational attainment · score 0.33
- Abnormal brain morphology · score 0.27
- mathematical ability · score 0.24
- cognitive function measurement · score 0.24
- cystatin C measurement · score 0.10
- hypoparathyroidism, familial isolated, 2 · score 0.04
- Primary hypomagnesemia with secondary hypocalcemia · score 0.04
- Familial isolated hypoparathyroidism · score 0.03
- pseudohypoparathyroidism type 2 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5U5X8-F1 | alphafold | PREDICTED | 49.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5U5X8.
Amino-acid sequence (452 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FAM222A?
The strongest Open Targets associations for FAM222A are angina pectoris, self reported educational attainment, Abnormal brain morphology, mathematical ability and cognitive function measurement.
How long is the FAM222A protein?
The Homo sapiens FAM222A protein (UniProt Q5U5X8) is 452 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5U5X8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5U5X8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.