Cytosolic carboxypeptidase 2 (AGBL2)
Homo sapiens — UniProt Q5U5Z8
Data last refreshed: (UniProt release unknown)
Key facts
Cytosolic carboxypeptidase 2 (AGBL2) is a protein from Homo sapiens identified by UniProt accession Q5U5Z8, 902 residues long. MolForge cross-references it against 0 known binders and 169 disease associations.
- UniProt accession: Q5U5Z8; gene symbol AGBL2.
- Organism: Homo sapiens.
- Length: 902 amino acids.
- Top disease associations (Open Targets): systolic blood pressure, diastolic blood pressure and Abnormal brain morphology.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytosolic carboxypeptidase 2 |
|---|---|
| UniProt accession | Q5U5Z8 |
| Gene | AGBL2 |
| Organism | Homo sapiens |
| Length | 902 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (169)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.30
- diastolic blood pressure · score 0.28
- Abnormal brain morphology · score 0.27
- lymphocyte count · score 0.18
- platelet component distribution width · score 0.15
- alcohol consumption measurement · score 0.15
- alcohol use disorder measurement · score 0.13
- chronotype measurement · score 0.12
- Rheumatoid arthritis · score 0.11
- lean body mass · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5U5Z8-F1 | alphafold | PREDICTED | 71.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5U5Z8.
Amino-acid sequence (902 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AGBL2?
The strongest Open Targets associations for AGBL2 are systolic blood pressure, diastolic blood pressure, Abnormal brain morphology, lymphocyte count and platelet component distribution width.
How long is the AGBL2 protein?
The Homo sapiens AGBL2 protein (UniProt Q5U5Z8) is 902 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5U5Z8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5U5Z8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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