Glycoprotein endo-alpha-1,2-mannosidase-like protein (MANEAL)
Homo sapiens — UniProt Q5VSG8
Data last refreshed: (UniProt release unknown)
Key facts
Glycoprotein endo-alpha-1,2-mannosidase-like protein (MANEAL) is a protein from Homo sapiens identified by UniProt accession Q5VSG8, 457 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q5VSG8; gene symbol MANEAL.
- Organism: Homo sapiens.
- Length: 457 amino acids.
- Top disease associations (Open Targets): eosinophil percentage of leukocytes, rheumatoid arthritis and mathematical ability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Glycoprotein endo-alpha-1,2-mannosidase-like protein |
|---|---|
| UniProt accession | Q5VSG8 |
| Gene | MANEAL |
| Organism | Homo sapiens |
| Length | 457 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- eosinophil percentage of leukocytes · score 0.14
- rheumatoid arthritis · score 0.13
- mathematical ability · score 0.13
- genetic disorder · score 0.12
- eosinophil count · score 0.11
- pulse pressure measurement · score 0.06
- vital capacity · score 0.05
- type 1 diabetes mellitus · score 0.04
- systemic lupus erythematosus · score 0.04
- pancreatic adenocarcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VSG8-F1 | alphafold | PREDICTED | 86.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VSG8.
Amino-acid sequence (457 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MANEAL?
The strongest Open Targets associations for MANEAL are eosinophil percentage of leukocytes, rheumatoid arthritis, mathematical ability, genetic disorder and eosinophil count.
How long is the MANEAL protein?
The Homo sapiens MANEAL protein (UniProt Q5VSG8) is 457 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VSG8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VSG8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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