G kinase-anchoring protein 1 (GKAP1)
Homo sapiens — UniProt Q5VSY0
Data last refreshed: (UniProt release unknown)
Key facts
G kinase-anchoring protein 1 (GKAP1) is a protein from Homo sapiens identified by UniProt accession Q5VSY0, 366 residues long. MolForge cross-references it against 0 known binders and 154 disease associations.
- UniProt accession: Q5VSY0; gene symbol GKAP1.
- Organism: Homo sapiens.
- Length: 366 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, triglyceride measurement and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | G kinase-anchoring protein 1 |
|---|---|
| UniProt accession | Q5VSY0 |
| Gene | GKAP1 |
| Organism | Homo sapiens |
| Length | 366 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (154)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- triglyceride measurement · score 0.31
- self reported educational attainment · score 0.31
- eosinophil count · score 0.27
- Alzheimer disease · score 0.26
- lysosomal storage disease · score 0.26
- Parkinson disease · score 0.26
- multiple sclerosis · score 0.26
- aspartate aminotransferase measurement · score 0.25
- neuroinflammatory disorder · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VSY0-F1 | alphafold | PREDICTED | 70.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VSY0.
Amino-acid sequence (366 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GKAP1?
The strongest Open Targets associations for GKAP1 are neurodegenerative disease, triglyceride measurement, self reported educational attainment, eosinophil count and Alzheimer disease.
How long is the GKAP1 protein?
The Homo sapiens GKAP1 protein (UniProt Q5VSY0) is 366 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VSY0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VSY0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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