E3 ubiquitin-protein ligase RNF220 (RNF220)
Homo sapiens — UniProt Q5VTB9
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF220 (RNF220) is a protein from Homo sapiens identified by UniProt accession Q5VTB9, 566 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.
- UniProt accession: Q5VTB9; gene symbol RNF220.
- Organism: Homo sapiens.
- Length: 566 amino acids.
- Top disease associations (Open Targets): leukodystrophy, hypomyelinating, 23, with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy, leukodystrophy and Ataxia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF220 |
|---|---|
| UniProt accession | Q5VTB9 |
| Gene | RNF220 |
| Organism | Homo sapiens |
| Length | 566 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (74)
Diseases linked to this target (Open Targets).
- leukodystrophy, hypomyelinating, 23, with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy · score 0.52
- leukodystrophy · score 0.38
- Ataxia · score 0.37
- Abnormal corpus callosum morphology · score 0.37
- Sensorineural hearing impairment · score 0.37
- heart rate response to recovery post exercise · score 0.29
- heart rate response to exercise · score 0.27
- heart rate · score 0.20
- resting heart rate · score 0.19
- diet measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VTB9-F1 | alphafold | PREDICTED | 58.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VTB9.
Amino-acid sequence (566 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF220?
The strongest Open Targets associations for RNF220 are leukodystrophy, hypomyelinating, 23, with ataxia, deafness, liver dysfunction, and dilated cardiomyopathy, leukodystrophy, Ataxia, Abnormal corpus callosum morphology and Sensorineural hearing impairment.
How long is the RNF220 protein?
The Homo sapiens RNF220 protein (UniProt Q5VTB9) is 566 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VTB9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VTB9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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