Zinc finger protein Gfi-1b (GFI1B)
Homo sapiens — UniProt Q5VTD9
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein Gfi-1b (GFI1B) is a protein from Homo sapiens identified by UniProt accession Q5VTD9, 330 residues long. MolForge cross-references it against 0 known binders and 154 disease associations.
- UniProt accession: Q5VTD9; gene symbol GFI1B.
- Organism: Homo sapiens.
- Length: 330 amino acids.
- Top disease associations (Open Targets): platelet-type bleeding disorder 17, mean platelet volume and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein Gfi-1b |
|---|---|
| UniProt accession | Q5VTD9 |
| Gene | GFI1B |
| Organism | Homo sapiens |
| Length | 330 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (154)
Diseases linked to this target (Open Targets).
- platelet-type bleeding disorder 17 · score 0.70
- mean platelet volume · score 0.69
- platelet count · score 0.68
- platelet component distribution width · score 0.63
- eosinophil count · score 0.53
- eosinophil percentage of leukocytes · score 0.52
- platelet crit · score 0.50
- reticulocyte count · score 0.49
- neutrophil count · score 0.49
- mean corpuscular volume · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VTD9-F1 | alphafold | PREDICTED | 63.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VTD9.
Amino-acid sequence (330 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GFI1B?
The strongest Open Targets associations for GFI1B are platelet-type bleeding disorder 17, mean platelet volume, platelet count, platelet component distribution width and eosinophil count.
How long is the GFI1B protein?
The Homo sapiens GFI1B protein (UniProt Q5VTD9) is 330 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VTD9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VTD9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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