RNA 2',3'-cyclic phosphatase ANGEL2 (ANGEL2)
Homo sapiens — UniProt Q5VTE6
Data last refreshed: (UniProt release unknown)
Key facts
RNA 2',3'-cyclic phosphatase ANGEL2 (ANGEL2) is a protein from Homo sapiens identified by UniProt accession Q5VTE6, 544 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: Q5VTE6; gene symbol ANGEL2.
- Organism: Homo sapiens.
- Length: 544 amino acids.
- Top disease associations (Open Targets): mathematical ability, self reported educational attainment and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA 2',3'-cyclic phosphatase ANGEL2 |
|---|---|
| UniProt accession | Q5VTE6 |
| Gene | ANGEL2 |
| Organism | Homo sapiens |
| Length | 544 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.15
- self reported educational attainment · score 0.13
- appendicular lean mass · score 0.06
- FRAXF syndrome · score 0.04
- age at menarche · score 0.03
- calf circumference measurement · score 0.01
- chronic kidney disease · score 0.01
- squamous cell carcinoma · score 0.00
- neoplasm · score 0.00
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VTE6-F1 | alphafold | PREDICTED | 74.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VTE6.
Amino-acid sequence (544 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ANGEL2?
The strongest Open Targets associations for ANGEL2 are mathematical ability, self reported educational attainment, appendicular lean mass, FRAXF syndrome and age at menarche.
How long is the ANGEL2 protein?
The Homo sapiens ANGEL2 protein (UniProt Q5VTE6) is 544 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VTE6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VTE6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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