About Fibronectin type III domain-containing protein 7
Fibronectin type III domain-containing protein 7 (FNDC7) is a protein
from Homo sapiens identified by UniProt accession
Q5VTL7, 733 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Fibronectin type III domain-containing protein 7 |
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| UniProt accession | Q5VTL7 |
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| Gene | FNDC7 |
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| Organism | Homo sapiens |
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| Length | 733 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.35
- hypertriglyceridemia 2 · score 0.06
- hypoalphalipoproteinemia, primary, 2, intermediate · score 0.06
- cholesterol-ester transfer protein deficiency · score 0.06
- plasma fibronectin deficiency · score 0.05
- Combined hyperlipidemia · score 0.05
- thyroid hormone metabolism, abnormal, 2 · score 0.05
- sitosterolemia · score 0.05
- homozygous familial hypercholesterolemia · score 0.05
- hypercholesterolemia, autosomal dominant, 3 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q5VTL7-F1 | alphafold | PREDICTED | 86.35 | — |
Amino-acid sequence (733 residues)
MAGGRETCLP LIGFILICLK MVASAKSAPE IPTIDQAYSK LSNSITVEWA TVPGATSYLL TAEDGDTVIE TTVANSPGTV TGLKAATWYE ITIRSISAAG RSQASPPKQA KTVLAAPILE VSSPSSDSIL VQWEAVYMAI AFSVSIMRAN GLGSIWKENT TNTSLTFTSL EAGTLYTIKA YAWNANRIPG DDSTCNQRTS PRAPANIQVS FDSGALKASF SWARAEGAFN YTVMALSDSS ELTCSTTFSS CTISSLQCGT EYLISVLASN DAGSSKSSSA MTLKTVACAP GRVTIQEDPP GHLSVAWSSV DLGDYYVVFV KSDDGLEVHC NTSLTQCNFL SECGFTYFIS VFVYNKAGQS PLGDIFNYTT APCCPSDINP VLVSSDRVEI VWSPVRGAEL YETKAVDGYN MVECNDTTPA CTLSALECDT KYNITVYSFN EVRGSNMSCT PQFITTAPCS PEIKNVSRDA FSMINVHWRS TNDDATYTVT AQGEKGLYQC SSTGESCTMR GLPCGSVFSV TAVAETQAGR SLPSYSVPLE TVPCCPTGLT VTQITQSVIN VSWTIGRVAQ THVAVLESHT GQSKCHTHQN HCLLGCITCG INYTVTLKAI SATGLTADCS YQSYFSGACC PLGVKLYRLG PNGIRIYWQA SRGSANYSTD LYGSKGIFTC TPSAGLSFCD VTEIPCGDVY TVMVSPVAKT GLKLTFCPKK IYSVTCSGST LGMVIYRGKR NEE
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