E3 ubiquitin-protein ligase BRE1A (RNF20)
Homo sapiens — UniProt Q5VTR2
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase BRE1A (RNF20) is a protein from Homo sapiens identified by UniProt accession Q5VTR2, 975 residues long. MolForge cross-references it against 0 known binders and 127 disease associations.
- UniProt accession: Q5VTR2; gene symbol RNF20.
- Organism: Homo sapiens.
- Length: 975 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean corpuscular volume and mean corpuscular hemoglobin.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase BRE1A |
|---|---|
| UniProt accession | Q5VTR2 |
| Gene | RNF20 |
| Organism | Homo sapiens |
| Length | 975 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (127)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- mean corpuscular volume · score 0.41
- mean corpuscular hemoglobin · score 0.39
- mean corpuscular hemoglobin concentration · score 0.18
- mean reticulocyte volume · score 0.17
- inflammatory bowel disease · score 0.08
- attention deficit hyperactivity disorder · score 0.07
- protein measurement · score 0.05
- Tourette syndrome · score 0.05
- neoplasm · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VTR2-F1 | alphafold | PREDICTED | 75.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VTR2.
Amino-acid sequence (975 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF20?
The strongest Open Targets associations for RNF20 are neurodegenerative disease, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and mean reticulocyte volume.
How long is the RNF20 protein?
The Homo sapiens RNF20 protein (UniProt Q5VTR2) is 975 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VTR2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VTR2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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