Cytosolic carboxypeptidase 6 (AGBL4)
Homo sapiens — UniProt Q5VU57
Data last refreshed: (UniProt release unknown)
Key facts
Cytosolic carboxypeptidase 6 (AGBL4) is a protein from Homo sapiens identified by UniProt accession Q5VU57, 503 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.
- UniProt accession: Q5VU57; gene symbol AGBL4.
- Organism: Homo sapiens.
- Length: 503 amino acids.
- Top disease associations (Open Targets): body mass index, unipolar depression and reaction time measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytosolic carboxypeptidase 6 |
|---|---|
| UniProt accession | Q5VU57 |
| Gene | AGBL4 |
| Organism | Homo sapiens |
| Length | 503 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (181)
Diseases linked to this target (Open Targets).
- body mass index · score 0.46
- unipolar depression · score 0.37
- reaction time measurement · score 0.37
- lean body mass · score 0.35
- calcium measurement · score 0.34
- smoking status measurement · score 0.33
- major depressive disorder · score 0.32
- cigarettes per day measurement · score 0.29
- schizophrenia · score 0.28
- smoking initiation · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VU57-F1 | alphafold | PREDICTED | 86.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VU57.
Amino-acid sequence (503 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AGBL4?
The strongest Open Targets associations for AGBL4 are body mass index, unipolar depression, reaction time measurement, lean body mass and calcium measurement.
How long is the AGBL4 protein?
The Homo sapiens AGBL4 protein (UniProt Q5VU57) is 503 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VU57 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VU57 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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