DDB1- and CUL4-associated factor 12-like protein 1 (DCAF12L1)
Homo sapiens — UniProt Q5VU92
Data last refreshed: (UniProt release unknown)
Key facts
DDB1- and CUL4-associated factor 12-like protein 1 (DCAF12L1) is a protein from Homo sapiens identified by UniProt accession Q5VU92, 463 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q5VU92; gene symbol DCAF12L1.
- Organism: Homo sapiens.
- Length: 463 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, male infertility with azoospermia or oligozoospermia due to single gene mutation and Down syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DDB1- and CUL4-associated factor 12-like protein 1 |
|---|---|
| UniProt accession | Q5VU92 |
| Gene | DCAF12L1 |
| Organism | Homo sapiens |
| Length | 463 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.27
- Down syndrome · score 0.05
- creatinine measurement · score 0.03
- urate measurement · score 0.02
- uric acid measurement · score 0.02
- handedness · score 0.02
- polycystic ovary syndrome · score 0.01
- infect · score 0.00
- infection · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VU92-F1 | alphafold | PREDICTED | 78.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VU92.
Amino-acid sequence (463 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCAF12L1?
The strongest Open Targets associations for DCAF12L1 are neurodegenerative disease, male infertility with azoospermia or oligozoospermia due to single gene mutation, Down syndrome, creatinine measurement and urate measurement.
How long is the DCAF12L1 protein?
The Homo sapiens DCAF12L1 protein (UniProt Q5VU92) is 463 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VU92 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VU92 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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