Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2)
Homo sapiens — UniProt Q5VUJ6
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2) is a protein from Homo sapiens identified by UniProt accession Q5VUJ6, 765 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q5VUJ6; gene symbol LRCH2.
- Organism: Homo sapiens.
- Length: 765 amino acids.
- Top disease associations (Open Targets): demyelinating polyneuropathy, cerebellar ataxia and Kleine-Levin Syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat and calponin homology domain-containing protein 2 |
|---|---|
| UniProt accession | Q5VUJ6 |
| Gene | LRCH2 |
| Organism | Homo sapiens |
| Length | 765 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- demyelinating polyneuropathy · score 0.33
- cerebellar ataxia · score 0.33
- Kleine-Levin Syndrome · score 0.11
- Isolated anophthalmia - microphthalmia · score 0.05
- Microphthalmia - ankyloblepharon - intellectual disability · score 0.05
- nanophthalmia · score 0.04
- microphthalmia · score 0.04
- nanophthalmos 2 · score 0.04
- endometrial carcinoma · score 0.02
- platelet count · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VUJ6-F1 | alphafold | PREDICTED | 62.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VUJ6.
Amino-acid sequence (765 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRCH2?
The strongest Open Targets associations for LRCH2 are demyelinating polyneuropathy, cerebellar ataxia, Kleine-Levin Syndrome, Isolated anophthalmia - microphthalmia and Microphthalmia - ankyloblepharon - intellectual disability.
How long is the LRCH2 protein?
The Homo sapiens LRCH2 protein (UniProt Q5VUJ6) is 765 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VUJ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VUJ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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