Dynein regulatory complex protein 8 (DRC8)
Homo sapiens — UniProt Q5VUJ9
Data last refreshed: (UniProt release unknown)
Key facts
Dynein regulatory complex protein 8 (DRC8) is a protein from Homo sapiens identified by UniProt accession Q5VUJ9, 269 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q5VUJ9; gene symbol DRC8.
- Organism: Homo sapiens.
- Length: 269 amino acids.
- Top disease associations (Open Targets): age-related macular degeneration, X-linked retinal dysplasia and choroidal dystrophy, central areolar, 1.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dynein regulatory complex protein 8 |
|---|---|
| UniProt accession | Q5VUJ9 |
| Gene | DRC8 |
| Organism | Homo sapiens |
| Length | 269 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- age-related macular degeneration · score 0.08
- X-linked retinal dysplasia · score 0.07
- choroidal dystrophy, central areolar, 1 · score 0.06
- Familial exudative vitreoretinopathy · score 0.06
- retinitis pigmentosa · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.06
- age related macular degeneration 4 · score 0.05
- age related macular degeneration 7 · score 0.05
- age related macular degeneration 11 · score 0.05
- coloboma of macula · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VUJ9-F1 | alphafold | PREDICTED | 64.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VUJ9.
Amino-acid sequence (269 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DRC8?
The strongest Open Targets associations for DRC8 are age-related macular degeneration, X-linked retinal dysplasia, choroidal dystrophy, central areolar, 1, Familial exudative vitreoretinopathy and retinitis pigmentosa.
How long is the DRC8 protein?
The Homo sapiens DRC8 protein (UniProt Q5VUJ9) is 269 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VUJ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VUJ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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