Succinate dehydrogenase assembly factor 4, mitochondrial (SDHAF4)
Homo sapiens — UniProt Q5VUM1
Data last refreshed: (UniProt release unknown)
Key facts
Succinate dehydrogenase assembly factor 4, mitochondrial (SDHAF4) is a protein from Homo sapiens identified by UniProt accession Q5VUM1, 108 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q5VUM1; gene symbol SDHAF4.
- Organism: Homo sapiens.
- Length: 108 amino acids.
- Top disease associations (Open Targets): mean platelet volume, type 2 diabetes mellitus and platelet component distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Succinate dehydrogenase assembly factor 4, mitochondrial |
|---|---|
| UniProt accession | Q5VUM1 |
| Gene | SDHAF4 |
| Organism | Homo sapiens |
| Length | 108 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.35
- type 2 diabetes mellitus · score 0.17
- platelet component distribution width · score 0.10
- gestational diabetes · score 0.05
- Dilated cardiomyopathy · score 0.03
- infect · score 0.01
- infection · score 0.01
- myocardial infarction · score 0.01
- adrenal gland pheochromocytoma · score 0.00
- Pallister-Hall syndrome · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VUM1-F1 | alphafold | PREDICTED | 65.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VUM1.
Amino-acid sequence (108 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SDHAF4?
The strongest Open Targets associations for SDHAF4 are mean platelet volume, type 2 diabetes mellitus, platelet component distribution width, gestational diabetes and Dilated cardiomyopathy.
How long is the SDHAF4 protein?
The Homo sapiens SDHAF4 protein (UniProt Q5VUM1) is 108 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VUM1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VUM1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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