Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PPRC1)

Homo sapiens — UniProt Q5VV67

Gene: PPRC1Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PPRC1) is a protein from Homo sapiens identified by UniProt accession Q5VV67, 1664 residues long. MolForge cross-references it against 0 known binders and 144 disease associations.

UniProt accession: Q5VV67; gene symbol PPRC1.
Organism: Homo sapiens.
Length: 1664 amino acids.
Top disease associations (Open Targets): mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration.
3D structure: AlphaFold model available.

Target properties

Protein name	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
UniProt accession	Q5VV67
Gene	PPRC1
Organism	Homo sapiens
Length	1664 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (144)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.29
mean corpuscular hemoglobin · score 0.27
mean corpuscular hemoglobin concentration · score 0.24
mean reticulocyte volume · score 0.24
monocyte percentage of leukocytes · score 0.17
genetic disorder · score 0.12
prostate carcinoma · score 0.11
prostate cancer · score 0.11
Familial prostate cancer · score 0.11
cancer · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VV67-F1	alphafold	PREDICTED	41.88	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VV67.

Amino-acid sequence (1664 residues)

MAARRGRRDG VAPPPSGGPG PDPGGGARGS GWGSRSQAPY GTLGAVSGGE QVLLHEEAGD SGFVSLSRLG PSLRDKDLEM EELMLQDETL LGTMQSYMDA SLISLIEDFG SLGESRLSLE DQNEVSLLTA LTEILDNADS ENLSPFDSIP DSELLVSPRE GSSLHKLLTL SRTPPERDLI TPVDPLGPST GSSRGSGVEM SLPDPSWDFS PPSFLETSSP KLPSWRPPRS RPRWGQSPPP QQRSDGEEEE EVASFSGQIL AGELDNCVSS IPDFPMHLAC PEEEDKATAA EMAVPAAGDE SISSLSELVR AMHPYCLPNL THLASLEDEL QEQPDDLTLP EGCVVLEIVG QAATAGDDLE IPVVVRQVSP GPRPVLLDDS LETSSALQLL MPTLESETEA AVPKVTLCSE KEGLSLNSEE KLDSACLLKP REVVEPVVPK EPQNPPANAA PGSQRARKGR KKKSKEQPAA CVEGYARRLR SSSRGQSTVG TEVTSQVDNL QKQPQEELQK ESGPLQGKGK PRAWARAWAA ALENSSPKNL ERSAGQSSPA KEGPLDLYPK LADTIQTNPI PTHLSLVDSA QASPMPVDSV EADPTAVGPV LAGPVPVDPG LVDLASTSSE LVEPLPAEPV LINPVLADSA AVDPAVVPIS DNLPPVDAVP SGPAPVDLAL VDPVPNDLTP VDPVLVKSRP TDPRRGAVSS ALGGSAPQLL VESESLDPPK TIIPEVKEVV DSLKIESGTS ATTHEARPRP LSLSEYRRRR QQRQAETEER SPQPPTGKWP SLPETPTGLA DIPCLVIPPA PAKKTALQRS PETPLEICLV PVGPSPASPS PEPPVSKPVA SSPTEQVPSQ EMPLLARPSP PVQSVSPAVP TPPSMSAALP FPAGGLGMPP SLPPPPLQPP SLPLSMGPVL PDPFTHYAPL PSWPCYPHVS PSGYPCLPPP PTVPLVSGTP GAYAVPPTCS VPWAPPPAPV SPYSSTCTYG PLGWGPGPQH APFWSTVPPP PLPPASIGRA VPQPKMESRG TPAGPPENVL PLSMAPPLSL GLPGHGAPQT EPTKVEVKPV PASPHPKHKV SALVQSPQMK ALACVSAEGV TVEEPASERL KPETQETRPR EKPPLPATKA VPTPRQSTVP KLPAVHPARL RKLSFLPTPR TQGSEDVVQA FISEIGIEAS DLSSLLEQFE KSEAKKECPP PAPADSLAVG NSGGVDIPQE KRPLDRLQAP ELANVAGLTP PATPPHQLWK PLAAVSLLAK AKSPKSTAQE GTLKPEGVTE AKHPAAVRLQ EGVHGPSRVH VGSGDHDYCV RSRTPPKKMP ALVIPEVGSR WNVKRHQDIT IKPVLSLGPA APPPPCIAAS REPLDHRTSS EQADPSAPCL APSSLLSPEA SPCRNDMNTR TPPEPSAKQR SMRCYRKACR SASPSSQGWQ GRRGRNSRSV SSGSNRTSEA SSSSSSSSSS SRSRSRSLSP PHKRWRRSSC SSSGRSRRCS SSSSSSSSSS SSSSSSSSSR SRSRSPSPRR RSDRRRRYSS YRSHDHYQRQ RVLQKERAIE ERRVVFIGKI PGRMTRSELK QRFSVFGEIE ECTIHFRVQG DNYGFVTYRY AEEAFAAIES GHKLRQADEQ PFDLCFGGRR QFCKRSYSDL DSNREDFDPA PVKSKFDSLD FDTLLKQAQK NLRR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with PPRC1?

The strongest Open Targets associations for PPRC1 are mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, mean reticulocyte volume and monocyte percentage of leukocytes.

How long is the PPRC1 protein?

The Homo sapiens PPRC1 protein (UniProt Q5VV67) is 1664 amino acids long.

Browse: Targets: P · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q5VV67 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q5VV67 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.