Interleukin-1 receptor-associated kinase 1-binding…

About Interleukin-1 receptor-associated kinase 1-binding protein 1

Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1BP1) is a protein from Homo sapiens identified by UniProt accession Q5VVH5, 260 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.

Target properties

Protein name	Interleukin-1 receptor-associated kinase 1-binding protein 1
UniProt accession	Q5VVH5
Gene	IRAK1BP1
Organism	Homo sapiens
Length	260 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (51)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.50
diastolic blood pressure · score 0.48
hypertension · score 0.38
cardiovascular disease · score 0.36
schizophrenia · score 0.34
mean platelet volume · score 0.33
self reported educational attainment · score 0.33
mathematical ability · score 0.32
response to high sodium diet · score 0.30
Agents acting on the renin-angiotensin system use measurement · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VVH5-F1	alphafold	PREDICTED	82.43	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VVH5.

Amino-acid sequence (260 residues)

MSLQKTPPTR VFVELVPWAD RSRENNLASG RETLPGLRHP LSSTQAQTAT REVQVSGTSE VSAGPDRAQV VVRVSSTKEA AAEAKKSVCR RLDYITQSLQ QQGVQAENIT VTKDFRRVEN AYHMEAEVCI TFTEFGKMQN ICNFLVEKLD SSVVISPPQF YHTPGSVENL RRQACLVAVE NAWRKAQEVC NLVGQTLGKP LLIKEEETKE WEGQIDDHQS SRLSSSLTVQ QKIKSATIHA ASKVFITFEV KGKEKRKKHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1BP1)