Deubiquitinase MYSM1 (MYSM1)
Homo sapiens — UniProt Q5VVJ2
Data last refreshed: (UniProt release unknown)
Key facts
Deubiquitinase MYSM1 (MYSM1) is a protein from Homo sapiens identified by UniProt accession Q5VVJ2, 828 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.
- UniProt accession: Q5VVJ2; gene symbol MYSM1.
- Organism: Homo sapiens.
- Length: 828 amino acids.
- Top disease associations (Open Targets): bone marrow failure syndrome, congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Deubiquitinase MYSM1 |
|---|---|
| UniProt accession | Q5VVJ2 |
| Gene | MYSM1 |
| Organism | Homo sapiens |
| Length | 828 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (112)
Diseases linked to this target (Open Targets).
- bone marrow failure syndrome · score 0.68
- congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome · score 0.55
- neurodegenerative disease · score 0.50
- Immunodeficiency · score 0.46
- Neurodevelopmental delay · score 0.46
- breast adenocarcinoma · score 0.21
- genetic disorder · score 0.19
- glioblastoma multiforme · score 0.18
- lung adenocarcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VVJ2-F1 | alphafold | PREDICTED | 64.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VVJ2.
Amino-acid sequence (828 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MYSM1?
The strongest Open Targets associations for MYSM1 are bone marrow failure syndrome, congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome, neurodegenerative disease, Immunodeficiency and Neurodevelopmental delay.
How long is the MYSM1 protein?
The Homo sapiens MYSM1 protein (UniProt Q5VVJ2) is 828 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VVJ2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VVJ2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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