Ubiquitin thioesterase OTU1 (YOD1)
Homo sapiens — UniProt Q5VVQ6
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin thioesterase OTU1 (YOD1) is a protein from Homo sapiens identified by UniProt accession Q5VVQ6, 348 residues long. MolForge cross-references it against 0 known binders and 100 disease associations.
- UniProt accession: Q5VVQ6; gene symbol YOD1.
- Organism: Homo sapiens.
- Length: 348 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, ovarian cancer and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin thioesterase OTU1 |
|---|---|
| UniProt accession | Q5VVQ6 |
| Gene | YOD1 |
| Organism | Homo sapiens |
| Length | 348 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (100)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.23
- ovarian cancer · score 0.23
- head and neck squamous cell carcinoma · score 0.20
- lung adenocarcinoma · score 0.18
- endometrial cancer · score 0.18
- urinary bladder cancer · score 0.18
- glomerular filtration rate · score 0.14
- creatinine measurement · score 0.12
- leukocyte count · score 0.12
- body height · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VVQ6-F1 | alphafold | PREDICTED | 80.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VVQ6.
Amino-acid sequence (348 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with YOD1?
The strongest Open Targets associations for YOD1 are glioblastoma multiforme, ovarian cancer, head and neck squamous cell carcinoma, lung adenocarcinoma and endometrial cancer.
How long is the YOD1 protein?
The Homo sapiens YOD1 protein (UniProt Q5VVQ6) is 348 amino acids long.
Browse: Targets: Y · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VVQ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VVQ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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