N-terminal Xaa-Pro-Lys N-methyltransferase 2 (NTMT2)
Homo sapiens — UniProt Q5VVY1
Data last refreshed: (UniProt release unknown)
Key facts
N-terminal Xaa-Pro-Lys N-methyltransferase 2 (NTMT2) is a protein from Homo sapiens identified by UniProt accession Q5VVY1, 283 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q5VVY1; gene symbol NTMT2.
- Organism: Homo sapiens.
- Length: 283 amino acids.
- Top disease associations (Open Targets): atrial fibrillation, atrial flutter and BMI-adjusted waist-hip ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N-terminal Xaa-Pro-Lys N-methyltransferase 2 |
|---|---|
| UniProt accession | Q5VVY1 |
| Gene | NTMT2 |
| Organism | Homo sapiens |
| Length | 283 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- atrial fibrillation · score 0.38
- atrial flutter · score 0.31
- BMI-adjusted waist-hip ratio · score 0.31
- drug use measurement · score 0.30
- cardiac arrhythmia · score 0.30
- cardiac edema · score 0.30
- leukocyte count · score 0.25
- appendicular lean mass · score 0.24
- intraocular pressure measurement · score 0.24
- BMI-adjusted waist circumference · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VVY1-F1 | alphafold | PREDICTED | 90.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VVY1.
Amino-acid sequence (283 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NTMT2?
The strongest Open Targets associations for NTMT2 are atrial fibrillation, atrial flutter, BMI-adjusted waist-hip ratio, drug use measurement and cardiac arrhythmia.
How long is the NTMT2 protein?
The Homo sapiens NTMT2 protein (UniProt Q5VVY1) is 283 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VVY1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VVY1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.