DDB1- and CUL4-associated factor 12-like protein 2 (DCAF12L2)

Homo sapiens — UniProt Q5VW00

Gene: DCAF12L2Homo sapiensSwissProt reviewed

About DDB1- and CUL4-associated factor 12-like protein 2

DDB1- and CUL4-associated factor 12-like protein 2 (DCAF12L2) is a protein from Homo sapiens identified by UniProt accession Q5VW00, 463 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.

Target properties

Protein nameDDB1- and CUL4-associated factor 12-like protein 2
UniProt accessionQ5VW00
GeneDCAF12L2
OrganismHomo sapiens
Length463 residues
Molecular weight—
EC numbers—
Target class—
Subcellular location—
Keywords—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tierMEDIUM
Druggability score—
Pocket score—
Max clinical phase—

Disease associations (101)

Diseases linked to this target (Open Targets).

  • lung adenocarcinoma · score 0.23
  • prostate adenocarcinoma · score 0.22
  • glioblastoma multiforme · score 0.21
  • non-small cell lung carcinoma · score 0.19
  • gastric carcinoma · score 0.18
  • oral squamous cell carcinoma · score 0.18
  • B-cell acute lymphoblastic leukemia · score 0.18
  • breast carcinoma · score 0.18
  • hepatocellular carcinoma · score 0.18
  • chronic lymphocytic leukemia · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

StructureSourceMethodMean pLDDTResolution (Å)
AF-Q5VW00-F1alphafoldPREDICTED79.61—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VW00.

Amino-acid sequence (463 residues)

MAQQQTGSRK RKAPAVEAGA GSSSSQGLAA ADGEGPLLPK KQKRPATRRR LVHYLKGREV GARGPAGLQG FEGELRGYAV QRLPELLTER QLDLGTLNKV FASQWLNARQ VVCGTKCNTL FVVDVQSGHI TRIPLMRDKE AGLAQAHQGC GIHAIELNPS KTLLATGGEN PNSLAIYQLP TLDPLCLGDR HGHKDWIFAV AWLSDTVAVS GSRDGTVALW RMDPDMFNGS IAWHSEVGLP VYAHIRPRDV EAIPRASTNP SNRKVRALAF SGKNQELGAV SLDGYFHLWK ARSTLSRLLS IRLPYCRENV CLTYCDELSL YAVGSQSHVS FLDPRQRQQN IRPLCSREGG TGVRSLSFYQ HIITVGTGHG SLLFYDIRAQ KFLEERASSS LDSMPGPAGR KLKLACGRGW LNQDDVWVNY FGGMGEFPNA LYTHCYNWPE MKLFVAGGPL PSGLHGNYAG LWS

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Quick facts

UniProtQ5VW00
GeneDCAF12L2
OrganismHomo sapiens
Length463
Binders0
Diseases101
View on UniProt