DDB1- and CUL4-associated factor 12-like protein 2 (DCAF12L2)
Homo sapiens — UniProt Q5VW00
Data last refreshed: (UniProt release unknown)
Key facts
DDB1- and CUL4-associated factor 12-like protein 2 (DCAF12L2) is a protein from Homo sapiens identified by UniProt accession Q5VW00, 463 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.
- UniProt accession: Q5VW00; gene symbol DCAF12L2.
- Organism: Homo sapiens.
- Length: 463 amino acids.
- Top disease associations (Open Targets): lung adenocarcinoma, prostate adenocarcinoma and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DDB1- and CUL4-associated factor 12-like protein 2 |
|---|---|
| UniProt accession | Q5VW00 |
| Gene | DCAF12L2 |
| Organism | Homo sapiens |
| Length | 463 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (101)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.23
- prostate adenocarcinoma · score 0.22
- glioblastoma multiforme · score 0.21
- non-small cell lung carcinoma · score 0.19
- gastric carcinoma · score 0.18
- oral squamous cell carcinoma · score 0.18
- B-cell acute lymphoblastic leukemia · score 0.18
- breast carcinoma · score 0.18
- hepatocellular carcinoma · score 0.18
- chronic lymphocytic leukemia · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VW00-F1 | alphafold | PREDICTED | 79.61 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VW00.
Amino-acid sequence (463 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DCAF12L2?
The strongest Open Targets associations for DCAF12L2 are lung adenocarcinoma, prostate adenocarcinoma, glioblastoma multiforme, non-small cell lung carcinoma and gastric carcinoma.
How long is the DCAF12L2 protein?
The Homo sapiens DCAF12L2 protein (UniProt Q5VW00) is 463 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VW00 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VW00 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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