Transcription initiation factor TFIID subunit 3 (TAF3)

About Transcription initiation factor TFIID subunit 3

Transcription initiation factor TFIID subunit 3 (TAF3) is a protein from Homo sapiens identified by UniProt accession Q5VWG9, 929 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.

Target properties

Protein name	Transcription initiation factor TFIID subunit 3
UniProt accession	Q5VWG9
Gene	TAF3
Organism	Homo sapiens
Length	929 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (43)

Diseases linked to this target (Open Targets).

HIV infection · score 0.58
protein measurement · score 0.38
neurodegenerative disease · score 0.37
erythrocyte count · score 0.32
mean reticulocyte volume · score 0.30
red blood cell density measurement · score 0.26
breast adenocarcinoma · score 0.25
ovarian cancer · score 0.23
neurofibrillary tangles measurement · score 0.21
lung adenocarcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VWG9-F1	alphafold	PREDICTED	55.05	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VWG9.

Amino-acid sequence (929 residues)

MCESYSRSLL RVSVAQICQA LGWDSVQLSA CHLLTDVLQR YLQQLGRGCH RYSELYGRTD PILDDVGEAF QLMGVSLHEL EDYIHNIEPV TFPHQIPSFP VSKNNVLQFP QPGSKDAEER KEYIPDYLPP IVSSQEEEEE EQVPTDGGTS AEAMQVPLEE DDELEEEEII NDENFLGKRP LDSPEAEELP AMKRPRLLST KGDTLDVVLL EAREPLSSIN TQKIPPMLSP VHVQDSTDLA PPSPEPPMLA PVAKSQMPTA KPLETKSFTP KTKTKTSSPG QKTKSPKTAQ SPAMVGSPIR SPKTVSKEKK SPGRSKSPKS PKSPKVTTHI PQTPVRPETP NRTPSATLSE KISKETIQVK QIQTPPDAGK LNSENQPKKA VVADKTIEAS IDAVIARACA EREPDPFEFS SGSESEGDIF TSPKRISGPE CTTPKASTSA NNFTKSGSTP LPLSGGTSSS DNSWTMDASI DEVVRKAKLG TPSNMPPNFP YISSPSVSPP TPEPLHKVYE EKTKLPSSVE VKKKLKKELK TKMKKKEKQR DREREKDKNK DKSKEKDKVK EKEKDKETGR ETKYPWKEFL KEEEADPYKF KIKEFEDVDP KVKLKDGLVR KEKEKHKDKK KDREKGKKDK DKREKEKVKD KGREDKMKAP APPLVLPPKE LALPLFSPAT ASRVPAMLPS LLPVLPEKLF EEKEKVKEKE KKKDKKEKKK KKEKEKEKKE KEREKEKRER EKREKEKEKH KHEKIKVEPV ALAPSPVIPR LTLRVGAGQD KIVISKVVPA PEAKPAPSQN RPKTPPPAPA PAPGPMLVSP APVPLPLLAQ AAAGPALLPS PGPAASGASA KAPVRSVVTE TVSTYVIRDE WGNQIWICPG CNKPDDGSPM IGCDDCDDWY HWPCVGIMTA PPEEMQWFCP KCANKKKDKK HKKRKHRAH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards