Lysophospholipase-like protein 1 (LYPLAL1)
Homo sapiens — UniProt Q5VWZ2
Data last refreshed: (UniProt release unknown)
Key facts
Lysophospholipase-like protein 1 (LYPLAL1) is a protein from Homo sapiens identified by UniProt accession Q5VWZ2, 237 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.
- UniProt accession: Q5VWZ2; gene symbol LYPLAL1.
- Organism: Homo sapiens.
- Length: 237 amino acids.
- Top disease associations (Open Targets): FEV/FVC ratio, appendicular lean mass and balding measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lysophospholipase-like protein 1 |
|---|---|
| UniProt accession | Q5VWZ2 |
| Gene | LYPLAL1 |
| Organism | Homo sapiens |
| Length | 237 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (143)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.37
- appendicular lean mass · score 0.36
- balding measurement · score 0.30
- intraocular pressure measurement · score 0.30
- lean body mass · score 0.30
- heel bone mineral density · score 0.28
- body height · score 0.28
- hematocrit · score 0.28
- erythrocyte count · score 0.27
- skin aging · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VWZ2-F1 | alphafold | PREDICTED | 95.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VWZ2.
Amino-acid sequence (237 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LYPLAL1?
The strongest Open Targets associations for LYPLAL1 are FEV/FVC ratio, appendicular lean mass, balding measurement, intraocular pressure measurement and lean body mass.
How long is the LYPLAL1 protein?
The Homo sapiens LYPLAL1 protein (UniProt Q5VWZ2) is 237 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VWZ2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VWZ2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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