About PRAME family member 6
PRAME family member 6 (PRAMEF6) is a protein
from Homo sapiens identified by UniProt accession
Q5VXH4, 476 residues long.
MolForge cross-references it against 0 known binders and
102 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (102)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failures 50 · score 0.08
- spermatogenic failure, X-linked, 2 · score 0.08
- spermatogenic failure 25 · score 0.08
- spermatogenic failure 63 · score 0.07
- isochromosomy Yp · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
- spermatogenic failure 61 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q5VXH4.
Amino-acid sequence (476 residues)
MSIRTPPRLL ELAGRSLLRD QALAMSTLEE LPTELFPPLF MEAFSRRRCE ALKLMVQAWP FRRLPLRPLI KMPCLEAFQA VLDGLDALLT QGVHPRRWKL QVLDLQDVCE NFWMVWSEAM ARGCFLNAKR NKTPVQDCPR MRGQQPLTVF VELWLKNRTL DEYLTCLLLW VKQRKDLLHL CCKKLKILGM PFRNIRSILK MVNLDCIQEV EVNCKWVLPI LTQFTPYLGH MRNLQKLVLS HMDVSRYVSP EQKKEIVTQF TTQFLKLCCL QKLSMNSVSF LEGHLDQLLS CLKTSLKVLT ITNCVLLESD LKHLSQCPSI SQLKTLDLSG IRLTNYSLVP LQILLEKVAA TLEYLDLDDC GIIDSQVNAI LPALSRCFEL NTFSFCGNPI SMATLENLLS HTIILKNLCV ELYPAPRESY DADGTLCWSR FAQIRAELMK RVRDLRHPKR ILFCTDCCPD CGNRSFYDLE ADQCCC
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