PRAME family member 7 (PRAMEF7)
Homo sapiens — UniProt Q5VXH5
Data last refreshed: (UniProt release unknown)
Key facts
PRAME family member 7 (PRAMEF7) is a protein from Homo sapiens identified by UniProt accession Q5VXH5, 474 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.
- UniProt accession: Q5VXH5; gene symbol PRAMEF7.
- Organism: Homo sapiens.
- Length: 474 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, azoospermia and partial chromosome Y deletion.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PRAME family member 7 |
|---|---|
| UniProt accession | Q5VXH5 |
| Gene | PRAMEF7 |
| Organism | Homo sapiens |
| Length | 474 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (103)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.29
- azoospermia · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failures 50 · score 0.08
- spermatogenic failure, X-linked, 2 · score 0.08
- spermatogenic failure 25 · score 0.08
- spermatogenic failure 63 · score 0.07
- isochromosomy Yp · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VXH5-F1 | alphafold | PREDICTED | 86.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VXH5.
Amino-acid sequence (474 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRAMEF7?
The strongest Open Targets associations for PRAMEF7 are neurodegenerative disease, azoospermia, partial chromosome Y deletion, spermatogenic failures 50 and spermatogenic failure, X-linked, 2.
How long is the PRAMEF7 protein?
The Homo sapiens PRAMEF7 protein (UniProt Q5VXH5) is 474 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VXH5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VXH5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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