Lipase member N (LIPN)
Homo sapiens — UniProt Q5VXI9
Data last refreshed: (UniProt release unknown)
Key facts
Lipase member N (LIPN) is a protein from Homo sapiens identified by UniProt accession Q5VXI9, 398 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q5VXI9; gene symbol LIPN.
- Organism: Homo sapiens.
- Length: 398 amino acids.
- Top disease associations (Open Targets): lamellar ichthyosis, blood protein measurement and autosomal recessive congenital ichthyosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lipase member N |
|---|---|
| UniProt accession | Q5VXI9 |
| Gene | LIPN |
| Organism | Homo sapiens |
| Length | 398 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- lamellar ichthyosis · score 0.52
- blood protein measurement · score 0.42
- autosomal recessive congenital ichthyosis · score 0.37
- lung adenocarcinoma · score 0.11
- cutaneous melanoma · score 0.11
- MODY · score 0.07
- 3-hydroxy-3-methylglutaryl-CoA synthase deficiency · score 0.05
- hyperproinsulinemia · score 0.05
- exercise-induced hyperinsulinism · score 0.04
- glycogen storage disorder due to hepatic glycogen synthase deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VXI9-F1 | alphafold | PREDICTED | 91.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VXI9.
Amino-acid sequence (398 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LIPN?
The strongest Open Targets associations for LIPN are lamellar ichthyosis, blood protein measurement, autosomal recessive congenital ichthyosis, lung adenocarcinoma and cutaneous melanoma.
How long is the LIPN protein?
The Homo sapiens LIPN protein (UniProt Q5VXI9) is 398 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VXI9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VXI9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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