Cysteine-rich hydrophobic domain-containing protein 1 (CHIC1)
Homo sapiens — UniProt Q5VXU3
Data last refreshed: (UniProt release unknown)
Key facts
Cysteine-rich hydrophobic domain-containing protein 1 (CHIC1) is a protein from Homo sapiens identified by UniProt accession Q5VXU3, 224 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q5VXU3; gene symbol CHIC1.
- Organism: Homo sapiens.
- Length: 224 amino acids.
- Top disease associations (Open Targets): prostate carcinoma, Familial prostate cancer and prostate cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cysteine-rich hydrophobic domain-containing protein 1 |
|---|---|
| UniProt accession | Q5VXU3 |
| Gene | CHIC1 |
| Organism | Homo sapiens |
| Length | 224 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- prostate carcinoma · score 0.11
- Familial prostate cancer · score 0.11
- prostate cancer · score 0.11
- medulloblastoma · score 0.02
- large cell medulloblastoma · score 0.02
- atypical teratoid rhabdoid tumor · score 0.01
- glioblastoma multiforme · score 0.01
- Sepsis · score 0.01
- septic shock · score 0.01
- primitive neuroectodermal tumor · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VXU3-F1 | alphafold | PREDICTED | 74.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VXU3.
Amino-acid sequence (224 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHIC1?
The strongest Open Targets associations for CHIC1 are prostate carcinoma, Familial prostate cancer, prostate cancer, medulloblastoma and large cell medulloblastoma.
How long is the CHIC1 protein?
The Homo sapiens CHIC1 protein (UniProt Q5VXU3) is 224 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VXU3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VXU3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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