Protein shortage in chiasmata 1 ortholog (SHOC1)
Homo sapiens — UniProt Q5VXU9
Data last refreshed: (UniProt release unknown)
Key facts
Protein shortage in chiasmata 1 ortholog (SHOC1) is a protein from Homo sapiens identified by UniProt accession Q5VXU9, 1444 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.
- UniProt accession: Q5VXU9; gene symbol SHOC1.
- Organism: Homo sapiens.
- Length: 1444 amino acids.
- Top disease associations (Open Targets): male infertility with azoospermia or oligozoospermia due to single gene mutation, azoospermia and testosterone measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein shortage in chiasmata 1 ortholog |
|---|---|
| UniProt accession | Q5VXU9 |
| Gene | SHOC1 |
| Organism | Homo sapiens |
| Length | 1444 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (121)
Diseases linked to this target (Open Targets).
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.38
- azoospermia · score 0.36
- testosterone measurement · score 0.30
- calcium measurement · score 0.30
- coronary artery disease · score 0.23
- genetic disorder · score 0.18
- body height · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- PHF-tau measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VXU9-F1 | alphafold | PREDICTED | 49.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VXU9.
Amino-acid sequence (1444 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SHOC1?
The strongest Open Targets associations for SHOC1 are male infertility with azoospermia or oligozoospermia due to single gene mutation, azoospermia, testosterone measurement, calcium measurement and coronary artery disease.
How long is the SHOC1 protein?
The Homo sapiens SHOC1 protein (UniProt Q5VXU9) is 1444 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VXU9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VXU9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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