Platelet endothelial aggregation receptor 1 (PEAR1)
Homo sapiens — UniProt Q5VY43
Data last refreshed: (UniProt release unknown)
Key facts
Platelet endothelial aggregation receptor 1 (PEAR1) is a protein from Homo sapiens identified by UniProt accession Q5VY43, 1037 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.
- UniProt accession: Q5VY43; gene symbol PEAR1.
- Organism: Homo sapiens.
- Length: 1037 amino acids.
- Top disease associations (Open Targets): mean platelet volume, blood protein measurement and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Platelet endothelial aggregation receptor 1 |
|---|---|
| UniProt accession | Q5VY43 |
| Gene | PEAR1 |
| Organism | Homo sapiens |
| Length | 1037 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (93)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.54
- blood protein measurement · score 0.39
- platelet count · score 0.39
- platelet aggregation · score 0.38
- platelet component distribution width · score 0.34
- refractive error measurement · score 0.34
- dickkopf‐related protein 1 measurement · score 0.24
- neutrophil count · score 0.24
- leukocyte count · score 0.23
- red blood cell density measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VY43-F1 | alphafold | PREDICTED | 68.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VY43.
Amino-acid sequence (1037 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PEAR1?
The strongest Open Targets associations for PEAR1 are mean platelet volume, blood protein measurement, platelet count, platelet aggregation and platelet component distribution width.
How long is the PEAR1 protein?
The Homo sapiens PEAR1 protein (UniProt Q5VY43) is 1037 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VY43 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VY43 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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