MAM and LDL-receptor class A domain-containing protein 1 (MALRD1)

Homo sapiens — UniProt Q5VYJ5

Gene: MALRD1Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

MAM and LDL-receptor class A domain-containing protein 1 (MALRD1) is a protein from Homo sapiens identified by UniProt accession Q5VYJ5, 2156 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

UniProt accession: Q5VYJ5; gene symbol MALRD1.
Organism: Homo sapiens.
Length: 2156 amino acids.
Top disease associations (Open Targets): pulse pressure measurement, cortical thickness and attention deficit hyperactivity disorder.
3D structure: AlphaFold model available.

Target properties

Protein name	MAM and LDL-receptor class A domain-containing protein 1
UniProt accession	Q5VYJ5
Gene	MALRD1
Organism	Homo sapiens
Length	2156 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

pulse pressure measurement · score 0.21
cortical thickness · score 0.13
attention deficit hyperactivity disorder · score 0.11
coagulation factor V measurement · score 0.10
cortical surface area measurement · score 0.08
heel bone mineral density · score 0.07
bone quantitative ultrasound measurement · score 0.06
brain measurement · score 0.06
blood protein measurement · score 0.06
cholangiocarcinoma · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VYJ5-F1	alphafold	PREDICTED	71.34	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VYJ5.

Amino-acid sequence (2156 residues)

MLFFLDRMLA FPMNETFCCL WIACVFNSTL AQQGTESFQC DNGVSLPPDS ICDFTDQCGD SSDERHCLNY ERCDFEDGLC HMTQDQSLQP SWTKRSGMIG LSPPFYDHNG DVSAHFLSLV SRVDSISSSL RSRVFLPTND QHDCQITFYY FSCQVSGKLM VGLQTACGGP IQHLWQNTAA LPNQWERNVI KIQSSQRFQV VFEGQMASTY EQDEVIAIDD ISFSSGCLPA NDGILLCQEA LNAERELCHP DTDLCRFDAT DEELRLCQAC GFEFDMCEWT SEASAGQISW MRTKAREIPA FESTPQQDQG GDDEGYYVWV GAKHGFTLNH LDSRAYLNSS VCHCLGKSCH LQFYYAMESS VLRVRLYNNK EEEIFWTYNI STHSQWVKAD VLIPEDLKTF KIIFEGTLLS QRSFIALDHL WVYACGQTQS RKLCSADEFP CTSGQCIAKE SVCDSRQDCS DESDEDPATC SKHLTCDFES GFCGWEPFLT EDSHWKLMKG LNNGEHHFPA ADHTANINHG SFIYLEAQRS PGVAKLGSPV LTKLLTASTP CQVQFWYHLS QHSNLSVFTR TSLDGNLQKQ GKIIRFSESQ WSHAKIDLIA EAGESTLPFQ LILEATVLSS NATVALDDIS VSQECEISYK SLPRTSTQSK FSKCDFEANS CDWFEAISGD HFDWIRSSQS ELSADFEHQA PPRDHSLNAS QGHFMFILKK SSSLWQVAKL QSPTFSQTGP GCILSFWFYN YGLSVGAAEL QLHMENSHDS TVIWRVLYNQ GKQWLEATIQ LGRLSQPFHL SLDKVSLGIY DGVSAIDDIR FENCTLPLPA ESCEGLDHFW CRHTRACIEK LRLCDLVDDC GDRTDEVNCA PELQCNFETG ICNWEQDAKD DFDWTRSQGP TPTLNTGPMK DNTLGTAKGH YLYIESSEPQ AFQDSAALLS PILNATDTKG CTFRFYYHMF GKRIYRLAIY QRIWSDSRGQ LLWQIFGNQG NRWIRKHLNI SSRQPFQILV EASVGDGFTG DIAIDDLSFM DCTLYPGNLP ADLPTPPETS VPVTLPPHNC TDNEFICRSD GHCIEKMQKC DFKYDCPDKS DEASCVMEVC SFEKRSLCKW YQPIPVHLLQ DSNTFRWGLG NGISIHHGEE NHRPSVDHTQ NTTDGWYLYA DSSNGKFGDT ADILTPIISL TGPKCTLVFW THMNGATVGS LQVLIKKDNV TSKLWAQTGQ QGAQWKRAEV FLGIRSHTQI VFRAKRGISY IGDVAVDDIS FQDCSPLLSP ERKCTDHEFM CANKHCIAKD KLCDFVNDCA DNSDETTFIC RTSSGRCDFE FDLCSWKQEK DEDFDWNLKA SSIPAAGTEP AADHTLGNSS GHYIFIKSLF PQQPMRAARI SSPVISKRSK NCKIIFHYHM YGNGIGALTL MQVSVTNQTK VLLNLTVEQG NFWRREELSL FGDEDFQLKF EGRVGKGQRG DIALDDIVLT ENCLSLHDSV QEELAVPLPT GFCPLGYREC HNGKCYRLEQ SCNFVDNCGD NTDENECGSS CTFEKGWCGW QNSQADNFDW VLGVGSHQSL RPPKDHTLGN ENGHFMYLEA TAVGLRGDKA HFRSTMWRES SAACTMSFWY FVSAKATGSI QILIKTEKGL SKVWQESKQN PGNHWQKADI LLGKLRNFEV IFQGIRTRDL GGGAAIDDIE FKNCTTVGEI SELCPEITDF LCRDKKCIAS HLLCDYKPDC SDRSDEAHCA HYTSTTGSCN FETSSGNWTT ACSLTQDSED DLDWAIGSRI PAKALIPDSD HTPGSGQHFL YVNSSGSKEG SVARITTSKS FPASLGMCTV RFWFYMIDPR SMGILKVYTI EESGLNILVW SVIGNKRTGW TYGSVPLSSN SPFKVAFEAD LDGNEDIFIA LDDISFTPEC VTGGPVPVQP SPCEADQFSC IYTLQCVPLS GKCDGHEDCI DGSDEMDCPL SPTPPLCSNM EFPCSTDECI PSLLLCDGVP DCHFNEDELI CSNKSCSNGA LVCASSNSCI PAHQRCDGFA DCMDFQLDES SCSECPLNYC RNGGTCVVEK NGPMCRCRQG WKGNRCHIKF NPPATDFTYA QNNTWTLLGI GLAFLMTHIT VAVLCFLANR KVPIRKTEGS GNCAFVNPVY GNWSNPEKTE SSVYSFSNPL YGTTSGSLET LSHHLK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with MALRD1?

The strongest Open Targets associations for MALRD1 are pulse pressure measurement, cortical thickness, attention deficit hyperactivity disorder, coagulation factor V measurement and cortical surface area measurement.

How long is the MALRD1 protein?

The Homo sapiens MALRD1 protein (UniProt Q5VYJ5) is 2156 amino acids long.

Browse: Targets: M · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q5VYJ5 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q5VYJ5 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.