Nucleoredoxin-like protein 2 (NXNL2)
Homo sapiens — UniProt Q5VZ03
Data last refreshed: (UniProt release unknown)
Key facts
Nucleoredoxin-like protein 2 (NXNL2) is a protein from Homo sapiens identified by UniProt accession Q5VZ03, 156 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: Q5VZ03; gene symbol NXNL2.
- Organism: Homo sapiens.
- Length: 156 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, smoking status measurement and neurofibrillary tangles measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nucleoredoxin-like protein 2 |
|---|---|
| UniProt accession | Q5VZ03 |
| Gene | NXNL2 |
| Organism | Homo sapiens |
| Length | 156 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- smoking status measurement · score 0.27
- neurofibrillary tangles measurement · score 0.26
- peripheral nervous system disease · score 0.20
- platelet count · score 0.16
- reticulocyte count · score 0.16
- mean corpuscular hemoglobin concentration · score 0.15
- lymphocyte count · score 0.15
- platelet crit · score 0.14
- reticulocyte measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VZ03-F1 | alphafold | PREDICTED | 91.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VZ03.
Amino-acid sequence (156 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NXNL2?
The strongest Open Targets associations for NXNL2 are neurodegenerative disease, smoking status measurement, neurofibrillary tangles measurement, peripheral nervous system disease and platelet count.
How long is the NXNL2 protein?
The Homo sapiens NXNL2 protein (UniProt Q5VZ03) is 156 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VZ03 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VZ03 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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