Izumo sperm-egg fusion protein 3 (IZUMO3)

About Izumo sperm-egg fusion protein 3

Izumo sperm-egg fusion protein 3 (IZUMO3) is a protein from Homo sapiens identified by UniProt accession Q5VZ72, 239 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.

Target properties

Protein name	Izumo sperm-egg fusion protein 3
UniProt accession	Q5VZ72
Gene	IZUMO3
Organism	Homo sapiens
Length	239 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (68)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.38
chronotype measurement · score 0.29
testosterone measurement · score 0.18
PHF-tau measurement · score 0.15
azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.08
Herpes Zoster · score 0.07
partial chromosome Y deletion · score 0.07
spermatogenic failure 20 · score 0.06
3-hydroxypropylmercapturic acid measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q5VZ72-F1	alphafold	PREDICTED	86.97	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VZ72.

Amino-acid sequence (239 residues)

MGDLWLFLLL PLSAFHGVKG CLECDPKFIE DVGSLLGNLI PSEVPGRTQL LERQIKEMIH LSFKVSHSDK RLRVLAVQQV VKLRTWLKNE FYKLGNETWK GVFIYQGKLL DVCQNLESKL KELLKNFSEI ACSEDCIVVE GPILDCWTCL RMTNRCFKGE YCGDEDPRKA ENREIALFLI LLATAVILGS AVLLFHFCIF HRRKMKAIRR SLKEYVEKKL EELMGKIDEK EEKDFRLRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards