Doublesex- and mab-3-related transcription factor A1 (DMRTA1)
Homo sapiens — UniProt Q5VZB9
Data last refreshed: (UniProt release unknown)
Key facts
Doublesex- and mab-3-related transcription factor A1 (DMRTA1) is a protein from Homo sapiens identified by UniProt accession Q5VZB9, 504 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.
- UniProt accession: Q5VZB9; gene symbol DMRTA1.
- Organism: Homo sapiens.
- Length: 504 amino acids.
- Top disease associations (Open Targets): sex hormone-binding globulin measurement, dentures and cortical surface area measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Doublesex- and mab-3-related transcription factor A1 |
|---|---|
| UniProt accession | Q5VZB9 |
| Gene | DMRTA1 |
| Organism | Homo sapiens |
| Length | 504 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (107)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.38
- dentures · score 0.36
- cortical surface area measurement · score 0.36
- type 2 diabetes mellitus · score 0.36
- cortical thickness · score 0.35
- brain measurement · score 0.34
- neuroimaging measurement · score 0.33
- chronic lymphocytic leukemia · score 0.32
- vital capacity · score 0.31
- diet measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VZB9-F1 | alphafold | PREDICTED | 56.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VZB9.
Amino-acid sequence (504 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DMRTA1?
The strongest Open Targets associations for DMRTA1 are sex hormone-binding globulin measurement, dentures, cortical surface area measurement, type 2 diabetes mellitus and cortical thickness.
How long is the DMRTA1 protein?
The Homo sapiens DMRTA1 protein (UniProt Q5VZB9) is 504 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VZB9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VZB9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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