F-actin-uncapping protein LRRC16A (CARMIL1)
Homo sapiens — UniProt Q5VZK9
Data last refreshed: (UniProt release unknown)
Key facts
F-actin-uncapping protein LRRC16A (CARMIL1) is a protein from Homo sapiens identified by UniProt accession Q5VZK9, 1371 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.
- UniProt accession: Q5VZK9; gene symbol CARMIL1.
- Organism: Homo sapiens.
- Length: 1371 amino acids.
- Top disease associations (Open Targets): platelet count, mean platelet volume and schizophrenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-actin-uncapping protein LRRC16A |
|---|---|
| UniProt accession | Q5VZK9 |
| Gene | CARMIL1 |
| Organism | Homo sapiens |
| Length | 1371 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (95)
Diseases linked to this target (Open Targets).
- platelet count · score 0.48
- mean platelet volume · score 0.47
- schizophrenia · score 0.42
- platelet component distribution width · score 0.40
- wellbeing measurement · score 0.39
- diet measurement · score 0.38
- platelet crit · score 0.36
- electrocardiography · score 0.36
- mean corpuscular hemoglobin · score 0.35
- BMI-adjusted waist-hip ratio · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VZK9-F1 | alphafold | PREDICTED | 67.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VZK9.
Amino-acid sequence (1371 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CARMIL1?
The strongest Open Targets associations for CARMIL1 are platelet count, mean platelet volume, schizophrenia, platelet component distribution width and wellbeing measurement.
How long is the CARMIL1 protein?
The Homo sapiens CARMIL1 protein (UniProt Q5VZK9) is 1371 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VZK9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VZK9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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