Protein-lysine methyltransferase METTL21C (METTL21C)
Homo sapiens — UniProt Q5VZV1
Data last refreshed: (UniProt release unknown)
Key facts
Protein-lysine methyltransferase METTL21C (METTL21C) is a protein from Homo sapiens identified by UniProt accession Q5VZV1, 264 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.
- UniProt accession: Q5VZV1; gene symbol METTL21C.
- Organism: Homo sapiens.
- Length: 264 amino acids.
- Top disease associations (Open Targets): HbA1c measurement, Red cell distribution width and facioscapulohumeral muscular dystrophy 4, digenic.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein-lysine methyltransferase METTL21C |
|---|---|
| UniProt accession | Q5VZV1 |
| Gene | METTL21C |
| Organism | Homo sapiens |
| Length | 264 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (7)
Diseases linked to this target (Open Targets).
- HbA1c measurement · score 0.19
- Red cell distribution width · score 0.17
- facioscapulohumeral muscular dystrophy 4, digenic · score 0.04
- mean platelet volume · score 0.02
- carcinoma of liver and intrahepatic biliary tract · score 0.02
- COVID-19 · score 0.01
- attention deficit hyperactivity disorder · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VZV1-F1 | alphafold | PREDICTED | 85.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VZV1.
Amino-acid sequence (264 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with METTL21C?
The strongest Open Targets associations for METTL21C are HbA1c measurement, Red cell distribution width, facioscapulohumeral muscular dystrophy 4, digenic, mean platelet volume and carcinoma of liver and intrahepatic biliary tract.
How long is the METTL21C protein?
The Homo sapiens METTL21C protein (UniProt Q5VZV1) is 264 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VZV1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VZV1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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