Phospholipid phosphatase 4 (PLPP4)
Homo sapiens — UniProt Q5VZY2
Data last refreshed: (UniProt release unknown)
Key facts
Phospholipid phosphatase 4 (PLPP4) is a protein from Homo sapiens identified by UniProt accession Q5VZY2, 271 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.
- UniProt accession: Q5VZY2; gene symbol PLPP4.
- Organism: Homo sapiens.
- Length: 271 amino acids.
- Top disease associations (Open Targets): body mass index, neurofibrillary tangles measurement and Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phospholipid phosphatase 4 |
|---|---|
| UniProt accession | Q5VZY2 |
| Gene | PLPP4 |
| Organism | Homo sapiens |
| Length | 271 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (63)
Diseases linked to this target (Open Targets).
- body mass index · score 0.34
- neurofibrillary tangles measurement · score 0.33
- Parkinson disease · score 0.33
- protein measurement · score 0.27
- endometrial cancer · score 0.23
- breast adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.21
- drug use measurement · score 0.13
- breast cancer · score 0.08
- lung carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q5VZY2-F1 | alphafold | PREDICTED | 91.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q5VZY2.
Amino-acid sequence (271 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLPP4?
The strongest Open Targets associations for PLPP4 are body mass index, neurofibrillary tangles measurement, Parkinson disease, protein measurement and endometrial cancer.
How long is the PLPP4 protein?
The Homo sapiens PLPP4 protein (UniProt Q5VZY2) is 271 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q5VZY2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q5VZY2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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