About ORC ubiquitin ligase 1
ORC ubiquitin ligase 1 (OBI1) is a protein
from Homo sapiens identified by UniProt accession
Q5W0B1, 726 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (52)
Diseases linked to this target (Open Targets).
- wellbeing measurement · score 0.29
- neuroticism measurement · score 0.21
- depressive symptom measurement · score 0.21
- pulse pressure measurement · score 0.21
- lymphocyte count · score 0.21
- body mass index · score 0.19
- body fat percentage · score 0.18
- conduct disorder · score 0.17
- lean body mass · score 0.17
- fat body mass · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q5W0B1.
Amino-acid sequence (726 residues)
MAQTVQNVTL SLTLPITCHI CLGKVRQPVI CINNHVFCSI CIDLWLKNNS QCPACRVPIT PENPCKEIIG GTSESEPMLS HTVRKHLRKT RLELLHKEYE DEIDCLQKEV EELKSKNLSL ESQIKTILDP LTLVQGNQNE DKHLVTDNPS KINPETVAEW KKKLRTANEI YEKVKDDVDK LKEANKKLKL ENGGLVRENL RLKAEVDNRS PQKFGRFAVA ALQSKVEQYE RETNRLKKAL ERSDKYIEEL ESQVAQLKNS SEEKEAMNSI CQTALSADGK GSKGSEEDVV SKNQGDSARK QPGSSTSSSS HLAKPSSSRL CDTSSARQES TSKADLNCSK NKDLYQEQVE VMLDVTDTSM DTYLEREWGN KPSDCVPYKD EELYDLPAPC TPLSLSCLQL STPENRESSV VQAGGSKKHS NHLRKLVFDD FCDSSNVSNK DSSEDDISRS ENEKKSECFS SPKTGFWDCC STSYAQNLDF ESSEGNTIAN SVGEISSKLS EKSGLCLSKR LNSIRSFEMN RTRTSSEASM DAAYLDKISE LDSMMSESDN SKSPCNNGFK SLDLDGLSKS SQGSEFLEEP DKLEEKTELN LSKGSLTNDQ LENGSEWKPT SFFLLSPSDQ EMNEDFSLHS SSCPVTNEIK PPSCLFQTEF SQGILLSSSH RLFEDQRFGS SLFKMSSEMH SLHNHLQSPW STSFVPEKRN KNVNQSTKRK IQSSLSSASP SKATKS
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